20 Best Venture Capital (VC) Firms in Boston

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If you’re on the hunt for venture capital to kickstart or boost your Boston-based startup, this article zeroes in on the top VC firms in Boston. 

We’re spotlighting six standout venture capital firms in Boston with a track record of backing successful startups. These firms aren’t just about funding; they like to forge partnerships that nurture growth and innovation. Whether you’re tech-focused or disrupting other sectors, these Boston VCs could be the game-changers you need.

Let’s get started and find you the right VC partner for your startup.

Accomplice

Accomplice is a VC firm and a contemporary family office co-founded by Jeff Fagnan and Ryan Moore. It’s known for having a patient investment approach​. Accomplice typically engages in deals ranging from 10 to 50 million dollars and focuses on startups valued between 100 to 500 million dollars. It has a strong track record, having been part of the story of several successful companies such as AngelList and Klaviyo.

Headquarters: USA 

Investment Geography: USA, Canada, Israel, UK, India, Japan, Singapore, Switzerland, Brazil, Liechtenstein, Portugal, Germany

Operating since: 2015

Investment Focus: B2B Software, Enterprise SaaS, Cyber Security, eSports, Gaming, Data Analytics, Emerging Hardware Platforms, AR/VR, Robotics, Marketplaces, Consumer Tech 

Stages: Seed, Series A

Number of investments: 366

Number of exits: 112

Check size: $ 10m – $50m

Notable investments: Klaviyo, Patreon, Angellist

Founders/Key People: Jeff Fagnan, Ryan Moore

Website: http://www.accomplice.co/ 

Advancit Capital

Advancit Capital is a venture capital firm focusing on investments in media, technology, and web3 startups. They aim to form long-term partnerships with entrepreneurs, offering not only capital but also access to a network and strategic support. Typically, their investments range between $5 and $10 million for startups valued at $50 to $100 million. Annually, they’re involved in about 7 to 12 investment rounds.

Headquarters: USA

Investment Geography: USA, UK, Italy, Canada, Germany, France, Sweden, Argentina

Operating since: 2011

Stages: Seed, Series A, Series B

Investment Focus: Media/Entertainment/Technology/Web 3 (Gaming, eSports, SportsTech, Content, Digital Media, Creative AI, SaaS/Software, FinTech, B2B, B2C)

Number of investments: 154

Number of exits: 68

Check size: $5-10m

Notable investments: Masterclass, Thrive Global, Mux

Founders/Key People: Jonathan Miller, Jason Ostheimer

Website: https://www.advancitcapital.com 

Bain Capital Ventures

Bain Capital Ventures is a multi-stage, domain-focused venture fund. The firm has over $10 billion in assets under management. It brings over 30 years of experience to the table, leveraging this expertise and a global network to support the growth of its portfolio companies. The firm’s investment approach recognizes and focuses on entrepreneurs who are deep thinkers and tenacious builders. Bain Capital Ventures primarily targets seed to growth-stage startups that use technology to disrupt existing markets or create new ones. 

Headquarters: USA

Investment Geography: USA, UK, Canada, Germany, Israel, France, India, China, Lithuania, Netherlands, Spain, Denmark, Finland, Brazil, Japan, Mexico, Italy

Operating since: 1984

Stages: Seed, Series A, Series B, Series C

Investment Focus: SaaS, Data Services, Infrastructure Software, CyberSecurity, FinTech, HealthCare, CommerceTech, ConsumerTech

Number of investments: 767

Number of exits: 231

Check size: $1m – $100m

Notable investments: Redis, LinkedIn

Founders/Key People: Ajay Agarwal, Zeeza Cole

Website: https://www.baincapitalventures.com 

Battery Ventures

Battery Ventures is a global, tech-focused investment firm. The firm has offices in the U.S., Europe, and Israel, and it practices a collaborative, research-focused style of investing. Battery Ventures has a broad portfolio with a history of more than 1,300 investments and over 500 exits​​​​​​​​. Regarding investment size, Battery Ventures has a wide range of check sizes, indicating a flexible investment strategy. Their check sizes range from $100K to as high as $50M. This range allows Battery Ventures to support startups at different growth phases and in various tech sectors.

Headquarters: USA

Investment Geography: USA, UK, Canada, Israel, Germany, France, India, Netherlands, Switzerland, Australia, Sweden, Ireland, Portugal, Malaysia, Belgium, Morocco, Singapore, Italy, Chile, Brazil, China, South Korea

Operating since: 1983

Stages: Seed, Series A, Series B, Series C

Investment Focus: Business Software, Enterprise IT, Cloud Computing, AI, Cyber Security, Online Marketplaces, Financial Technology, Health Care IT, Industrial Technology

Number of investments: 1384

Number of exits: 528

Check size: $100k – $50m

Notable investments: Amplitude, Coinbase

Founders/Key People: Morad Elhafed, Dharmesh Thakker

Website: https://www.battery.com 

Boston Seed Capital

Established in 2011, Boston Seed Capital operates out of Boston, Massachusetts. The firm is known for its strategic investments in the IT sector​​. Boston Seed Capital provides seed-stage funding for internet-enabled businesses, both consumer and B2B SaaS companies, and supporting services marketplaces.

Headquarters: USA

Investment Geography: USA, Israel, Brazil

Operating since: 2011

Stages: Seed, Series A 

Investment Focus: Consumer Digital, Sports & Marketplaces, Artificial Intelligence, Data Analytics, CyberSecurity, B2B Software

Number of investments: 127

Number of exits: 49

Check size: $100k – $300k

Notable investments: Flywire, Draftkings, Perch

Founders/Key People: Peter Blacklow, Estelle Palandjian

Website: https://bostonseed.com 

Data Point Capital

Data Point Capital is a venture capital firm primarily focused on the Internet sector. Based in Boston, Massachusetts, the firm comprises business executives and internet leaders with substantial experience in creating value by developing successful companies. They operate with a philosophy of being entrepreneurs who assist other entrepreneurs. Data Point Capital has been involved in building numerous successful ventures, leveraging their expertise to foster growth and innovation in internet-focused startups​​.

Headquarters: USA

Investment Geography: USA, India, Greece

Operating since: 2012

Stages: Seed,Series A

Investment Focus: Consumer Internet (E-commerce,Mobile,Media),Enterprise Software,Cyber Security,AdTech,MarTech,JobTech,HRTech,eSports,FoodTech,IIoT,Marketplaces

Number of investments: 51

Number of exits: 13

Check size: $100k – $3m

Notable investments: FlexCar, JobGet

Founders/Key People: Geoff Oblak, Scott Savitz

Website: https://datapointcapital.com 

G20 Ventures

G20 Ventures is a venture capital firm based in Boston, Massachusetts. They specialize in providing early traction capital to East Coast enterprise tech startups. The firm focuses on assisting these startups in developing and scaling their products and services. Additionally, G20 Ventures offers resources and connections to support the growth and success of these startups. They have a particular interest in investing in early-stage Web3 companies and communities. Their team comprises professionals with diverse industry backgrounds dedicated to fostering startup success. G20 Ventures typically offers a check size ranging from $2M to $6M​​.

Headquarters: USA

Investment Geography: USA, Germany, Israel, Spain, Colombia

Operating since: 2013

Stages: Series A,Series B

Investment Focus: Enterprise Tech (Enterprise Software,AI,Big Data,Data Analytics, FinTech, PropTech, Cyber Security, HRTech,MarTech,AdTech,SalesTech,E-commerce,Manufacturing)

Number of investments: 47

Number of exits: 10

Check size: $2M to $6M​​

Notable investments: Siemplify, Fuze

Founders/Key People: Bill Wiberg, Bob Hower

Website: https://www.g20vc.com 

Glasswing Ventures

Glasswing Ventures is a venture capital firm that invests in early-stage companies, particularly those harnessing AI and frontier technologies for transforming enterprise and security markets. The firm distinguishes itself with a deep commitment to diversity and expertise in the field and aims to serve as an extension of founding teams. Their “Building Partner Vision” reflects this approach, offering robust support across domains like go-to-market strategies, product development, engineering, and finance. Glasswing Ventures 

Headquarters: USA

Investment Geography: USA, Canada, Brazil, Singapore

Operating since: 2016

Stages: Pre-Seed, Seed, Series A

Investment Focus: AI & Frontier Tech (Intelligent Enterprise, Data Analytics, Cloud, Business Intelligence, Enterprise Software, CyberSecurity, MarTech)

Number of investments: 71

Number of exits: 11

Check size: $500k – $3m

Notable investments: Reprise, Inrupt

Founders/Key People: Rudina Seseri, Rick Grinnell

Website: https://glasswing.vc 

Gutbrain Ventures

Gutbrain Ventures is a venture capital firm based in Boston, Massachusetts. It focuses on seed-stage, early-stage, and later-stage investments across various sectors, including business and consumer products and services, manufacturing, and SaaS. The firm is known for its primary investment in enterprise software companies. Gutbrain Ventures is praised for its partnership approach, guiding companies through growth to successful exits, and is recognized for supporting women entrepreneurs and CEOs.

Headquarters: USA

Investment Geography: USA, Canada

Operating since: 2018

Stages: Seed,Series A,Series B

Investment Focus: Enterprise Software, B2B SaaS

Number of investments: 81

Number of exits: 8

Check size: $3m to $41m

Notable investments: aPriori Technologies

Founders/Key People: Bob Davoli 

Website: https://www.gutbrainventures.com

Hyperplane VC

Hyperplane Venture Capital is a venture firm that supports founders with the vision to build groundbreaking companies for the future, even those whose ideas might seem unconventional today. They focus on early-stage technology companies in areas such as machine intelligence, AI, distributed systems, and more, aiming to drive innovation across all industries through software, hardware, and AI. Their approach is based on partnership, patience, and a deep commitment to solving the world’s biggest challenges, backing gritty, visionary founders ready to make a significant impact​​.  

Headquarters: USA (Boston, Massachusetts)

Investment Geography: USA

Operating since: 2014

Stages: Seed, Series A

Investment Focus: Enterprise DeepTech (AI, ML, Machine Intelligence, Data Science, Data Analytics, VR & AR, Computer Vision, Enterprise Software, Cloud Computing, Robotics, Sensor Tech, Distributed Systems, Supply Chain, E-commerce, AgTech, LegalTech, HealthTech, Digital Health, Cyber Security, FinTech)

Number of investments: 112

Number of exits: 17

Check size: $100k – $3m

Notable investments: SportsVisio, CoSell, Lucid Data, Flexpa, Soft Robotics

Founders/Key People: Vivian Myrto, Brendan Kohler, John Murphy

Website: http://www.hyperplane.vc/ 

Indicator Ventures

Indicator Ventures is an early-stage venture capital firm that has been established and focuses on investing in transformational companies at their earliest stages. The firm targets technology companies that promise to make work, life, and wealth-building easier and more accessible. With a lean and collaborative team, Indicator Ventures positions itself as a lead investor during the critical initial stages of a company’s growth, supporting over 70 portfolio companies across three successful funds.

Headquarters: United States.

Investment Geography: United States, Spain, Singapore, Australia.

Operating since: 2014

Investment Focus: Enterprise Software, AI, ML, Big Data, EdTech, Digital Health, HealthTech, MarTech, AdTech, FinTech, Crypto, MediaTech, Digital Media, E-commerce, Social, VR, eSports, HRTech, Airspace.

Stages: Seed, Series A,

Number of investments: 85

Number of exits: 11

Check size: $100K – $1M

Notable investments: Lob, Almanac

Founders/Key People: Geoffrey Bernstein

Website: https://www.indicatorventures.com/

MassMutual Ventures (CVC)

MassMutual Ventures (MMV) is a multi-stage global venture capital firm founded in 2014 as a venture capital arm of MassMutual Financial Group. Headquartered in Boston, Massachusetts, MMV specializes in investments across various domains, including enterprise software, cybersecurity, financial technology, digital health, and climate technology companies. The firm plays an active role in the growth of the companies it invests in by providing capital, connections, and strategic advice.

Headquarters: USA

Investment Geography: United States, Singapore, India, United Kingdom, Israel, Canada, Austria, Australia, Indonesia, Hong Kong, Hungary, France.

Operating since: 2014.

Investment Focus: B2B Enterprise Software,Cyber Security,FinTech,Digital Health.

Stages: Pre-seed, Seed, Post-Seed, Series A, Series B+.

Number of investments: 127

Number of exits: 16

Check size: $100K – $5M

Notable investments: RiskIQ, Nydig

Founders/Key People: Eric Emmons, Mark Goodman

Website: https://massmutualventures.com/

Mendoza Ventures

Established in 2016, Mendoza Ventures is a venture capital firm based in Boston, Massachusetts, specializing in early and growth-stage investments. The firm is particularly focused on the Fintech, AI, and Cybersecurity sectors. Mendoza Ventures stands out for its actively managed approach to venture capital, investing in areas where the team has substantial domain expertise.

Headquarters: USA

Investment Geography: USA, UK, Canada

Operating since: 2016

Investment Focus: AI,FinTech,Cyber Security,Blockchain,SaaS,E-commerce

Stage: Pre-Seed, Seed, Post-Seed, Series A.

Number of investments: 15

Number of exits: 2

Check size: $100K – $5M

Notable investments: SensoAI, FiVerity

Founders/Key People: Susana Hirs, Adrian Mendoza

Website: https://mendoza-ventures.com

OneWay Ventures

OneWay Ventures, established in 2017 and headquartered in Boston, MA, is a seed-stage venture capital firm known for its unique focus on investing in immigrant founders. The firm predominantly invests in technology sector companies. OneWay Ventures is distinctive for its commitment to bringing together immigrant founders and fostering a community that shares the common experience of adapting to new countries, cultures, and environments.  This expansion enables them to lead institutional seed rounds more effectively. The firm’s portfolio includes various companies, notably in sectors like machine learning, fintech, and edtech.

Headquarters: USA (Boston, Massachusetts)

Investment Geography: USA, Canada + notable investment in African fintech sector (with Chipper Cash)

Operating since: 2017

Investment Focus: Therapeutics, Medical Devices, MedTech, Diagnostics, Digital Health, HealthTech, SaaS, FinTech, EdTech, Marketplaces, E-commerce, Digital Media, Enterprise Software, Business Intelligence, HRTech, EnergyTech, Mobility, Telecom

Stages: Series A, Series B, Series C

Number of investments: 91

Number of exits: 3

Check size: $500k – $3m

Notable investments: Instock, Chipper Cash, Corvus Robotics, Billdr

Founders/Key People: Semyon Dukach

Website: https://www.onewayvc.com/ 

OpenView

OpenView is a venture capital firm that supports business software companies, particularly those at the expansion stage. Founded in 2006, OpenView focuses on partnering with and investing in companies that have the potential to become market leaders in their field. The firm provides financial and operational support, emphasizing growth in areas like sales, marketing, product-led growth, talent, and corporate development.

Headquarters: USA (Boston, Massachusetts)

Investment Geography: US, Canada, Australia.

Operating since: 2006

Investment Focus: Enterprise Software (Logistics, Supply Chain, IoT, Cyber Security, MarTech, SalesTech,Dev Tools,Workflow Management, Communication, Meetings, Analytics, LegalTech, EdTech, Cloud, Real Estate, Data Storage, Field Management, HealthTech)

Stages: Series A, Series B, Series C

Number of investments: 154

Number of exits: 50

Check size: $100k – $5m

Notable investments: Calendly, Datadog, Instructure, Acronis

Founders/Key People: Scott Maxwell, Daniel Demmer

Website: https://www.openspace.vc/ 

Optum Ventures

Optum Ventures is a venture capital firm that focuses on transforming healthcare. It operates as the investment arm of Optum, partnering with promising entrepreneurs to fundamentally change healthcare systems. The firm leverages its significant healthcare market expertise and experience to bring innovative solutions to market swiftly and efficiently. Optum Ventures is particularly interested in startups and early-stage companies that develop digital health technologies and innovations. These include platforms and applications that enhance healthcare delivery, diagnostics, and patient care, often using artificial intelligence and machine learning.

Headquarters: USA (Boston, Massachusetts)

Investment Geography: USA

Operating since: 2017

Investment Focus: Digital Health (Software, Cloud Infrastructure, AI, ML, Data Analytics)

Stages: Series A, Series B

Number of investments: 83

Number of exits: 10

Check size: $100k – $5m

Notable investments: Somatus, Dispatch Health, Truepill, LetsGetChecked

Founders/Key People: Larry C. Renfro, Laura Veroneau, Kaylan Alderson

Website: www.optumventures.com 

Polaris Partners

Polaris Partners, founded in 1996, is a venture capital firm focused on healthcare and biotechnology. With over 25 years of experience, the firm has backed many transformational companies in these sectors. They have offices in Boston, Massachusetts, New York, NY, and San Francisco, California. Polaris Partners has funded over 400 companies, achieved over 100 exits, and facilitated over 50 IPOs. The firm emphasizes its role as builders and advisors, not just investors, leveraging a network of prestigious companies, universities, and research institutions.

Headquarters: USA (Boston, Massachusetts)

Investment Geography: USA

Operating since: 1996

Investment Focus: Health Care (BioTech, Biopharma, Biomedical), Technology (Software, Tech-Enabled Services, Consumer Internet)

Stages: Series A, Series B, Series C

Number of investments: 938

Number of exits: 351

Check size: $300k – $2m

Notable investments: LogMeIn, Nomad Health, Dewpoint

Founders/Key People: Brian Chee, Dave Barrett, Marissa Bertorelli

Website: https://polarispartners.com/ 

PJC

PJC, founded in 2001, is a venture capital firm based in Boston, Massachusetts. They specialize in early-stage investments, focusing on pre-seed, seed, and Series A rounds across various industries in the United States. They have a diverse investment portfolio, which includes over 100 companies across North America, with notable investments in firms like Expensify, Nest, BlockFi, GetWell Network, and Nexamp. They primarily focus on consumer and enterprise technology investments. PJC is known for investing in, supporting, and building relationships with entrepreneurs shaping the future.

Headquarters: USA (Boston, Massachusetts)

Investment Geography: USA and Canada 

Operating since: 2001

Investment Focus: Consumer Tech, IoT, FinTech/InsurTech, Consumer Internet, Digital Health/HealthTech, EnergyTech, Software/SaaS, B2B/Enterprise, MarTech, HRTech, PropTech

Stages: Pre-Seed, Seed, Series A

Number of investments: 185

Number of exits: 77

Check size: $100k – $5m

Notable investments: Expensify, Nest, Openly, Eden Health, TrueNorth, Nexamp, Synthesis AI, GetWell Network, BlockFi

Founders/Key People: Marissa Milbury, David Martirano

Website: https://www.pjc.vc/ 

Sigma Prime Ventures

Sigma Prime Ventures is a venture capital firm headquartered in Boston, Massachusetts, founded in 2012. The firm primarily invests in early-stage companies operating in sectors such as SaaS, cloud, mobile, disruptive technologies, and technology-enabled services. Sigma Prime Ventures is known for its hands-on investment approach, leveraging its team’s extensive entrepreneurial and operational experience to support the growth and development of its portfolio companies.

Headquarters: United States

Investment Geography: United States, United Kingdom.

Operating since: 2012

Investment Focus: SaaS/Software, Cloud, Mobile, Disruptive Tech, Tech-Enabled Services

Stage: Pre-Seed, Seed, Series A, Series B.

Number of investments: 94

Number of exits: 21

Check size: $100K – $1M

Notable investments: WordStream, NS1

Founders/Key People: John Simon

Website: http://www.sigmaprime.com/

Underscore VC

Underscore VC is a venture capital firm based in Boston, Massachusetts, established in 2015. The firm specializes in backing bold early-stage entrepreneurs and aligns a community designed to fit each startup’s unique needs. Underscore VC focuses on investments across various sectors, including B2B, SaaS, fintech, technology, biotech, healthcare, e-commerce, cloud computing, logistics, finance, and life sciences. 

Headquarters: United States

Investment Geography: United States, France, Canada, Singapore

Operating since: 2015

Investment Focus: SaaS, Cloud Infrastructure, Edge Computing, Enterprise Software, AI/ML, Data Analytics, Robotics, IoT, Blockchain, Computer Vision, AR/VR, FinTech, InsurTech, Crypto, HRTech, E-commerce, MarTech, Real Estate Tech, Construction Tech, Marketplaces

Stage: Pre-Seed, Seed, Series A, Series B.

Number of investments: 84

Number of exits: 10

Check size: $10K – $1M

Notable investments: H1, Coda

Founders/Key People: Lily Lyman

Website: https://underscore.vc/

Conclusion

That’s a wrap on your tour of Boston’s finest venture capital firms. These 20 VC firms in Boston are more than just funding partners; they’re catalysts for turning bold ideas into market realities.

As you take the next steps with your startup, consider these firms for their financial backing, expertise, connections, and commitment to growth. Remember, the right VC partner is out there, one that aligns with your vision and is as excited about your success as you are.

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